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The growing threat of antimicrobial resistance (AMR) is well recognised. Low- and middle- income countries are likely to be more severely affected due to overstretched health systems and poor access to alternative antibiotic regimes. This information sheet details the DRUM project’s adoptive One Health approach to understanding how water, sanitation and hygiene practices interact with antimicrobial usage to facilitate the transmission of AMR-bacteria in Uganda & Malawi.